Update on the Global Fund’s Eighth Replenishment and Implications for GC8

25 November 2025

In a message to country partners, the Global Fund thanked donors and country partners for the efforts made towards the Global Fund’s Eighth Replenishment, which has so far raised US$11.34 billion. A few key donors indicated they would pledge as soon as possible.

The Replenishment result – while still partial – reflects the changing realities shaping today’s global health landscape. In this context, the Global Fund’s unique partnership model remains strong, but there is no doubt that its approach to Grant Cycle 8 (GC8) must evolve. With expected tighter funding, the partnership must work smarter together.

Most countries will receive reduced country allocations for GC8 and will need to make difficult but necessary decisions to selectively target investments to protect HIV, TB and malaria outcomes and sustain momentum, and at the same time, more rigorously use Global Fund investments in a catalytic manner in complementarity with domestic budgets and other funding.

The partnership will be working together to adapt by: accelerating transition timelines and working towards self-reliance where applicable; maximizing outcomes through prioritization and integration; and by focusing on most at risk populations and expediting access to innovations.

The Global Fund will introduce changes in GC8 including revamping its approach to co-financing, sharpening the focus on transition planning, supporting public financial management, and further opening its pooled procurement mechanism, introducing pre-financing, so countries can buy quality-assured life-saving commodities at the lowest price.

In practical terms, the Global Fund will continue to support countries throughout preparations for the GC8 cycle, as follows:

1. GC8 applicant investment guidance and funding request forms will be published during the second half of December on the Global Fund website. These documents may undergo further refinement after the Global Fund Board meeting in February.
2. Global Fund sessions will provide additional information to support the in-country investment prioritization and subsequent development of funding requests. Information on how to register for the sessions is available here.
3. Country allocation decisions will be finalized after the Board meeting and qualitative adjustment discussions in February.
4. Allocation letters will be shared with eligible countries that receive an allocation in March.